When must a pharmacy use a DEA 222 form to distribute controlled substances?

The requirement to use a DEA 222 form when distributing controlled substances is primarily associated with the most restricted classes of controlled substances, specifically Schedule I (CI) and Schedule II (CII) substances. The DEA 222 form is a crucial document in the controlled substance regulatory framework, as it serves as an official record of the transfer of these highly regulated medications.

Schedule I substances are considered to have a high potential for abuse and currently have no accepted medical use in treatment in the United States, necessitating strict controls over their distribution. Schedule II substances, while they do have medical uses, also carry a high potential for abuse and have strict regulations governing their handling and distribution. The use of the DEA 222 form ensures that there is an official, traceable mechanism for the procurement of these substances from manufacturers, wholesalers, or distributors.

Other schedules of controlled substances, such as Schedule III (CIII), IV (CIV), and V (CV), do not require the use of a DEA 222 form for distribution. Instead, there are different processes in place that do not necessitate the same level of control. This distinction is fundamental in understanding the legal and regulatory landscape concerning controlled substances in pharmacies.