What principle applies to organizations or people that carry out pharmaceutical activities involving controlled substances?

The principle that organizations or individuals must register with the DEA when involved in handling controlled substances is fundamental to the regulation of these substances in the United States. This requirement is set forth in the Controlled Substances Act, which mandates that anyone who manufactures, distributes, dispenses, or conducts research with controlled substances must obtain a registration from the DEA.

This registration is crucial because it serves to ensure that those who are handling controlled substances are legally authorized to do so, thereby helping to prevent unlawful access and potential abuse of these powerful drugs. The DEA uses this registration process to conduct background checks, oversee compliance with federal regulations, and monitor the distribution of controlled substances to maintain public health and safety.

The other choices reflect misunderstandings of the regulatory landscape surrounding controlled substances. For instance, merely having a business license is insufficient, as it does not address the specific legal requirements for handling controlled substances. Collaborating with registered entities without needing one's own registration would undermine the regulatory framework designed to ensure accountability and safety. Lastly, while there may be very limited exemptions under specific circumstances, the general rule requires DEA registration for any activity involving controlled substances, making the correct option clear.