What must control procedures ensure about suppositories in non-sterile compounding?

In non-sterile compounding, control procedures must ensure that suppositories are properly sealed. Proper sealing is critical to maintain the integrity and effectiveness of the suppositories. Sealing helps to prevent contamination, protect the active ingredients from degradation, and ensure that the dosage form remains intact until it is administered to the patient.

Proper sealing also helps to comply with regulatory requirements, which mandate that compounded medications must be prepared in a way that ensures safety and quality. Without proper sealing, the risk of contamination and loss of potency increases, potentially compromising patient safety.

While the other options may seem relevant, they do not address the critical aspects of safety and quality control that proper sealing ensures. For example, suppositories can be formulated in various colors depending on the drug and excipients used, but color is not a control measure for safety. Melting is not a recommended practice as it may compromise the formulation, and documentation is essential for accountability and tracking but is not specific to the requirement for security in the final product.