What is one of the control procedures in non-sterile compounding?

In non-sterile compounding, one of the essential control procedures is the evaluation of uniformity and homogeneity. This is crucial to ensure that the final compounded product is consistent and effective. Uniformity refers to the consistency of the formulation throughout the entire product, which is particularly important when dealing with active pharmaceutical ingredients (APIs) that may have a potent effect even in small variations of dosage.

Ensuring homogeneity means verifying that the active ingredient is evenly distributed within the compounded product, which directly affects the therapeutic outcomes. A lack of homogeneity can lead to underdosing or overdosing patients, thus compromising efficacy and safety.

Weight variation is important, but +/- 5% is generally more applicable to certain dosage forms rather than a broad control procedure. While checking for pH is also important, especially for specific formulations that require a certain pH range for stability or efficacy, it does not encompass the overall control of the entire compounding process as evaluating uniformity and homogeneity does. Control procedures are indeed required in non-sterile compounding to ensure the quality and safety of the medication being prepared.