Under what condition may an APRN prescribe C2 substances?

The correct answer pertains to the requirement that an Advanced Practice Registered Nurse (APRN) must obtain a certain level of clinical experience—specifically, 2 years or 2000 hours—before being allowed to prescribe controlled substances classified as Schedule II (C2). This condition ensures that the APRN has sufficient training and experience to manage the complexities associated with prescribing potent medications that have a higher potential for abuse and dependency.

This regulatory framework aims to protect patients by ensuring that only those APRNs who have demonstrated substantial clinical competency can prescribe C2 substances, which are often used for pain management and other serious medical conditions. Therefore, the emphasis on clinical experience directly correlates with the level of responsibility that comes with prescribing these powerful drugs.

In contrast, the options related to simply needing any physician's approval, possessing a special license, or only being allowed to prescribe in a hospital setting do not align with the established regulations and training requirements for APRNs in regards to C2 substances. Each of these alternative scenarios lacks the depth of training and practical experience guaranteed by the 2000 hours or 2 years requirement, which is fundamental for ensuring safe and effective patient care when prescribing C2 drugs.