True or False: Each place of business involved in manufacturing, distributing, or dispensing controlled substances requires separate registration with the DEA.

The statement is true because under the federal Controlled Substances Act, each separate location that manufactures, distributes, or dispenses controlled substances must have its own registration with the Drug Enforcement Administration (DEA). This requirement ensures that each facility is individually accountable for the controlled substances they handle, allowing for better regulation and oversight of these substances.

The rationale behind this requirement is to provide a clear framework for monitoring the distribution and use of controlled substances across different locations. Each facility may have different operational risks and needs, and individual registrations help the DEA assess compliance and conduct inspections based on those unique factors.

Regarding other options, suggesting that registration depends on business size doesn't align with legal standards, as all businesses must register regardless of size. Similarly, stating registration is only necessary for Schedule I substances is incorrect since all controlled substances, regardless of their schedule, require separate registrations per facility.