In non-sterile compounding, control of uniformity in size is crucial for solid dosage forms to ensure that they are consistent and intact. This means that the individual units, whether they are tablets, capsules, or powders, have a uniform size, which is essential for accurate dosing and ensuring the therapeutic effect of the compounded preparation. Uniformity in size helps to ensure that each dose contains the intended amount of active ingredient, thereby minimizing variations in potency that could lead to underdosing or overdosing.
Maintaining uniformity also supports the physical stability of the dosage forms. When the sizes are consistent, the risk of breakage or other physical defects often decreases, contributing to the overall integrity of the product. These factors collectively help to enhance the efficacy and safety of the medication being compounded.